MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential |
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| Authors: | Marta Fernandez-Mercado Lorea Manterola Charles H. Lawrie |
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| Affiliation: | aOncology area, Biodonostia Research Institute, San Sebastián, Spain; ;bNuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK;;cIKERBASQUE, Basque Foundation for Science, Bilbao, Spain. |
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| Abstract: | Although it is now evident that microRNAs (miRNAs) play a critical regulatory role in many, if not all, pathological and physiological processes, remarkably they have only formally been recognized for less than fifteen years. These endogenously produced short non-coding RNAs have created a new paradigm of gene control and have utility as both novel biomarkers of cancer and as potential therapeutics. In this review we consider the role of miRNAs in lymphoid biology both under physiological (i.e. lymphopoiesis) and malignant (i.e. lymphomagenesis) conditions. In addition to the functional significance of aberrant miRNA expression in lymphomas we discuss their use as novel biomarkers, both as a in situ tumour biomarker and as a non-invasive surrogate for the tumour by testing miRNAs in the blood of patients. Finally we consider the use of these molecules as potential therapeutic agents for lymphoma (and other cancer) patients and discuss some of the hurdles yet to be overcome in order to translate this potential into clinical practice |
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| Keywords: | Biomarker Hematological malignancies Lymphoid Lymphoma microRNA ncRNA. |
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