ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease

Recently, the rs1042713 G > A and rs1042714 C > G polymorphisms in the beta-2adrenergic receptor (ADRB2) gene were shown to be related to atherosclerosisdiseases. Therefore, we performed a systemic meta-analysis to determine whether thetwo functional polymorphisms are related to the risk of myocardial infarction (MI)and coronary artery disease (CAD). We identified published studies that are relevantto our topic of interest. Seven case-control studies, with a total of 6,843 subjects,were incorporated into the current meta-analysis. Our analysis showed a higherfrequency of rs1042713 G > A variant in patients with MI or CAD compared tohealthy controls. A similar result was also obtained with the rs1042714 C > Gvariant under both the allele and dominant models. Ethnicity-stratified subgroupanalysis suggested that the rs1042714 C > G variant correlated with an increasedrisk of the two diseases in both Asians and Caucasians, while rs1042713 G > A onlycontributes to the risk of two diseases in Asians. In the disease type-stratifiedsubgroups, the frequencies of both the rs1042713 G > A and rs1042714 C > Gvariants were higher in the cases than in the controls in both the MI and CADsubgroups. Collectively, our data contribute towards understanding the correlationbetween the rs1042713 G > A and rs1042714 C > G polymorphisms inADRB2 and the susceptibility to MI and CAD.