Sialoglycans in protozoal diseases: Their detection, modes of acquisition and emerging biological roles |
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Authors: | Anil K Chava Sumi Bandyopadhyay Mitali Chatterjee Chitra Mandal |
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Institution: | (1) Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata, 700 032, India;(2) Department of Pharmacology, Dr, BC Roy Postgraduate Institute of Basic Medical Sciences, I.P.G.M.E.R., 244B A.J.C. Bose Road, Kolkata, 700 020, India |
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Abstract: | Protozoan parasites including Plasmodia, Leishmania, Trypanosoma, Entamoeba, Trichomonas and others cause diseases in humans and domestic livestock having far-reaching socio-economic implications. They show remarkable
propensity to survive within hostile environments encountered during their life cycle, and the identification of molecules
that enable them to survive in such milieu is a subject of intense research. Currently available knowledge of the parasite
cell surface architecture and biochemistry indicates that sialic acid and its principle derivatives are major components of
the glycocalyx and assist the parasite to interact with its external environment through functions ranging from parasite survival,
infectivity and host-cell recognition. This review highlights the present state of knowledge with regard to parasite sialobiology
with an emphasis on its mode(s) of acquisition and their emerging biological roles, notably as an anti-recognition molecule
thereby aiding the pathogen to evade host defense mechanisms. Published in 2004.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | sialic acid O-acetylated sialic acid parasite trans-sialidases UDP-GlcNAc2-epimerase |
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