神经干细胞巢成分及调节机制的研究进展

神经干细胞（NSCs）是一类具有自我更新和多向分化潜能的细胞。在特定的条件下能够分化成神经元、星形胶质细胞和少突胶质细胞，从而参与神经发生和损伤修复。调节NSCs的特定微环境，通常称为神经干细胞巢，包括多个细胞群，其贡献目前正在积极探索。了解NSCs及其微环境成分之间的相互作用，对于开发治疗神经退行性疾病及脊髓损伤的疗法至关重要。本篇综述描述并讨论了最新的研究，确定了新的成分在神经干细胞巢中的作用。这些发现给这个领域带来了新的概念。本综述评估这些最新进展，提高对NSCs微环境及其对NSCs功能的影响的认识。

Research progress on composition and regulatory mechanism ofneural stem cell niche

Neural stem cells (NSCs) are stem cells that with the ability of self-renew and multipledifferentiation potential. Under certain circumstances, NSCs are able to differentiate into neurons, astrocytes and oligodendrocytes, thereby participating in the neurogenesis and injury repair. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between neural stem cells and their niche components is essential for the development of therapies against neurodegenerative disorders and spinal cord injury. In this review, we describe and discuss recent studies that identified novel components in the neural stem cell niche. These discoveries bring new concepts to the field. Therefore, we evaluate these recent advances that change our understanding of the neural stem cell niche and its influence on neural stem cell function.