Factors Influencing Virulence and Plaque Properties of Attenuated Venezuelan Equine Encephalomyelitis Virus Populations |
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| Authors: | Henry J. Hearn Zenonas V. Seliokas Arthur A. Andersen |
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| Affiliation: | Biological Sciences Laboratories, Fort Detrick, Frederick, Maryland 27101 |
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| Abstract: | A minority of stable large-plaque virus increased proportionally in stored unstable attenuated (9t) Venezuelan equine encephalomyelitis virus populations. L-cell-grown progeny (9t2) of stored 9t showed large amounts of large-plaque virus and increased virulence. Small-plaque virus inhibited large-plaque virus but not the reverse. Serial passage of small-plaque virus from 9t2 yielded a strain (20t) that was more attenuated than 9t. |
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