Identification and characterisation of a novel splice variant of the human CB1 receptor |
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Authors: | Ryberg Erik Vu Huy Khang Larsson Niklas Groblewski Thierry Hjorth Stephan Elebring Thomas Sjögren Sven Greasley Peter J |
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Affiliation: | Department of Molecular Pharmacology, AstraZeneca R&D, M?lndal, Sweden. |
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Abstract: | Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues. |
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Keywords: | 2-AG, 2-arachidonoylglycerol CP55940, (−)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol WIN55,212-2, R(_)-[2,3-di-hydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benz-oxazinyl]-(1-naphthalenyl)-methanone-mesylate HU210, (−)11-OH-8-tetrahydrocannabinol-dimethylheptyl Δ9-THC, Δ9-tetrahydrocannabinol SR141716, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-pyrazole-3-carboxamide GTPγS, guanosine 5′-[γ-35S]-triphosphate OEA, oleoylethanolamide PEA, palmitoylethanolamide PEI, polyethyleneimine PCR, polymerase chain reaction |
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