Control of growth and differentiation by cyclic AMP in fungi |
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Authors: | Tatsuo Ishikawa |
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Institution: | (1) School of Science and Engineering, Teikyo University, Nagaoka-cho, 320 Utsunomiya |
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Abstract: | InSaccharomyces cerivisiae intracellular cAMP mediates environmental signals that regulate cellular metabolism and growth. The studies on the cAMP-requiring
mutants and their suppressors in the yeast revealed that cAMP-dependent protein phosphorylation is involved in the G1 phase
of the cell cycle, stimulation of the phosphoinositide pathway and the post-meiotic stage of spourlation, and that inhibition
of cAMP-dependent protein phosphorylation is required to go into the GO stage of and to induce meiotic division. Growth of
some filamentous fungi was observed with significantly reduced levels of cAMP, suggesting that cAMP may not be essential for
growth in some species of fungi. Germination of fungal spores, yeast-mycelium dimorphism and hyphal morphogenesis of several
species of fungi were affected by cAMP. cAMP was involved in extension of hyphae, formation of hyphal aggregates and fruit
body formation. Phosphorylation of cellular proteins is required in these processes, and the nature of these proteins phosphorylated
by cAMP-dependent protein kinase is important to the understanding of the role of cAMP for growth and differentistion in fungal
cells. |
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Keywords: | cAMP cascade system Phosphoinositide pathway Cell cycle Sporulation Hyphal morphogenesis Fruit body formation |
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