Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis |
| |
| Authors: | Reznick Richard M Zong Haihong Li Ji Morino Katsutaro Moore Irene K Yu Hannah J Liu Zhen-Xiang Dong Jianying Mustard Kirsty J Hawley Simon A Befroy Douglas Pypaert Marc Hardie D Grahame Young Lawrence H Shulman Gerald I |
| |
| Institution: | Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. |
| |
| Abstract: | Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging. |
| |
| Keywords: | HUMDISEASE |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
