Rabbit liver fructose 1,6-bisphosphatase: the sequence of the amino-terminal region. |
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| Authors: | H A El-Dorry D K Chu A Dzugaj O Tsolas S Pontremoli B L Horecker |
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| Affiliation: | 1. Roche Institute of Molecular Biology, Nutley, New Jersey 07110 U.S.A.;1. Institute of Biological Chemistry, University of Genoa, Genoa, Italy |
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| Abstract: | A cyanogen bromide peptide, isolated from the NH2-terminus of rabbit liver FruP2ase, has been shown to have the following structure: Acetyl-Ala-Asp-Lys-Ala-Pro-Phe-Asp-Thr-Asp-Ile-Ser-Thr-Met-Thr-Arg-Phe-Val-Met. Previous evidence that the enzyme contains tryptophan located near the NH2-terminus and also that this tryptophan is lost on exposure of the enzyme to lysosomal fractions must be reevaluated. It is unlikely that the NH2-terminus would be reacetylated following proteolytic modification of this portion of the molecule. |
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