Segregation of allotypes in a strain of chickens homozygous for theB locus |
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| Authors: | Juraj Ivanyi Peter M. Lydyard |
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| Affiliation: | (1) Present address: Department of Pediatrics, University of Alabama in Birmingham, 35294 Alabama;(2) Department of Experimental Immunobiology, Welleome Research Laboratories, BR3 3BS Beckenham, Kent, England |
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| Abstract: | Sublines homozygous for alleles controlling IgM and IgG allotypes at two linked loci (M1 andG1) were established in the B14 strain of chickens, which is homozygous for theB locus controlling major histocompatibility antigens. Transfer of lymphoid cells resulted in a permanent donor-type IgG synthesis in irradiated 12-day-old recipients, but was followed by protracted rejection in chickens injected embryonally. |
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