Penicillin production by mutants ofPenicillium chrysogenum resistant to polyene macrolide antibiotics |
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Authors: | Jose M Luengo Gloria Revilla Manuel J López Julio R Villanueva Juan F Martin |
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Institution: | (1) Departamento de Microbiología, Facultades de Ciencias y Farmacia, Universida de Salamanca, Salamanca, Spain |
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Abstract: | Summary Polyene-resistant mutants ofPenicillium chrysogenum Wis. 54–1255 have been obtained by stepwise selection in increasing concentrations of polyene antibiotics. From the parent strain, sensitive to 10 g/ml of polyene antibiotics, mutants resistant to fungimycin (1.3 mg/ml), amphotericin B (0. 5 mg/ml), or nystatin (167 g//ml) were obtained. Their penicillin production is different from that of the parent strain and in particular some of the fungimycin-resistant mutants produce higher levels of penicillin. |
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