Characterization of mutations that enhance position-effect variegation in Drosophila melanogaster |
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Authors: | Donald A. R. Sinclair Vett K. Lloyd Thomas A. Grigliatti |
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Affiliation: | (1) Department of Zoology, University of British Columbia, V6T 2A9 Vancouver, British Columbia, Canada |
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Abstract: | Summary Several mutants that enhance the gene inactivation associated with position-effect variegation [E(var) mutants] have been characterized. These include three ethyl methanesulfonate (EMS)-induced lesions and a second chromosome duplication. Each of the EMS mutations maps to a discrete euchromatic site on the third chromosome. One is located within the chromosomal region occupied by a cluster of Su(var) mutations. All four E(var) mutants enhance the inactivation of several different variegators and therefore they appear to influence position-effect variegation generally. However, the enhancement caused by the single site E(var) mutations is less striking than that caused by the duplication or by loss of the Y chromosome. The interaction between the E(var) mutants and selected Su(var) mutations, as well as the effects of extra Y heterochromatin on E(var) expression, have also been investigated. Based on the results of these studies, various hypothetical functions of the E(var)+ products are suggested. |
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Keywords: | Enhancers of position-effect variegation |
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