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Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

Authors:	Aaron Ciechanover

Institution:	Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel

Abstract:

Keywords:	ODC ornithine decarboxylase G6PD glucose-6-phosphate dehydrogenase PEPCK phosphoenol-pyruvate carboxykinase TAT tyrosine aminotransferase APF-1 ATP-dependent proteolysis factor 1 (ubiquitin) UBIP ubiquitous immunopoietic polypeptide (ubiquitin) MCP multicatalytic proteinase complex (26S proteasome) CP 20S core particle (of the proteasome) RP 19S regulatory particle (of the proteasome)
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