Specific functions of lysosomal proteases in endocytic and autophagic pathways |
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Authors: | Sabrina Mü ller,Julia Dennemä rker,Thomas Reinheckel |
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Affiliation: | a Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, D-79104, Germanyb Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germanyc Dept. of Visceral Surgery, Albert-Ludwigs-University Freiburg, Freiburg, Germanyd BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany |
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Abstract: | Endolysosomal vesicles form a highly dynamic multifunctional cellular compartment that contains multiple highly potent proteolytic enzymes. Originally these proteases have been assigned to cooperate solely in executing the unselective ‘bulk proteolysis’ within the acidic milieu of the lysosome. Although to some degree this notion still holds true, evidence is accumulating for specific and regulatory functions of individual ‘acidic’ proteases in many cellular processes linked to the endosomal/lysosomal compartment. Here we summarize and discuss the functions of individual endolysosomal proteases in such diverse processes as the termination of growth factor signaling, lipoprotein particle degradation, infection, antigen presentation, and autophagy. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. |
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Keywords: | Protease Autophagy Endocytosis Phagocytosis Protein turnover |
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