The human cornea has a high incidence of acquired chromosome abnormalities |
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| Authors: | M J Pettenati Andrew J Sweatt Patrick Lantz Constance A Stanton James Reynolds P Nagesh Rao Richard M Davis |
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| Institution: | (1) Department of Pediatrics, Section on Medical Genetics, Medical Center Blvd, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA Fax: 910-716-2554, US;(2) Department of Ophthalmology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157, USA, US;(3) Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA, US;(4) Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA, US;(5) Shodair Hospital, Helena, MT 59604, USA, SH |
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| Abstract: | Structurally and functionally, the human cornea is a highly specialized tissue. The corneal stromal collagen matrix is uniquely
transparent and yet maintains a mechanically tough and chemically impermeable barrier between the eye and environment. We
report for the first time that stromal keratocytes of the human cornea show cytogenetic abnormalities with a frequency that
is unprecedented among normal tissues. The abnormalities are acquired, clonal and nonclonal, primarily aneuploid in nature,
and present in normal as well as diseased corneas.
Received: 10 February 1997 / Accepted: 21 May 1997 |
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