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Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives |
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| Authors: | Rao Yerra Koteswara Fang Shih-Hua Tzeng Yew-Min |
| Affiliation: | aInstitute of Biotechnology, Chaoyang University of Technology, Wufeng 413, Taiwan, ROC bDepartment of Microbiology, School of Medicine, China Medical University, Taichung 400, Taiwan, ROC |
| Abstract: | As a continuation of our search for potential new anticancer agents, a series of ten flavonoid derivatives has been synthesized by cyclization of substituted chalcones. Target compounds were evaluated for their biological activity. Among them, compounds 1–4 and 9 displayed a significant growth inhibitory action against a panel of tumor cell lines including Jurkat, PC-3, and Colon 205. On treatment with an equitoxic (IC50) concentration, compounds 1–5 and 7–9 blocked cells in the G2/M phase of the Jurkat cell cycle, whereas compound 6 blocked the same in the G0/G1 phase. |
| Keywords: | Flavonoids Natural product synthesis Cytotoxicity Cell cycle analysis |
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