| 单羧酸转运泵基因家族研究进展 |
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| 引用本文： | 张桂芝,黄桂君,郭先健. 单羧酸转运泵基因家族研究进展[J]. 生物化学与生物物理进展, 2001, 28(2): 172-175 |
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| 作者姓名： | 张桂芝 黄桂君 郭先健 |
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| 作者单位： | 第三军医大学全军呼吸内科研究所，重庆 400037 |
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| 摘 要： | 单羧酸转运泵（monocarboxylate transporter，MCT）是哺乳动物细胞中的重要跨膜蛋白，涉及细胞的多种功能，包括胞内pH值调节及乳酸跨膜转运等.目前，已克隆出至少8个MCT亚型的cDNA，构成了哺乳动物细胞离子转运泵的一个新基因家族.各亚型具有底物和抑制剂的特异性以及组织学分布的差异性.因此，研究MCT的结构功能及调控机制，将可能为肿瘤等疾病诊治提供新的手段.
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| 关 键 词： | 单羧酸转运蛋白，乳酸，肿瘤 |
| 收稿时间： | 2000-03-24 |
| 修稿时间： | 2000-06-07 |
Advances in the Study of the MCT Gene Family |
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| ZHANG Gui-Zhi,HUANG Gui-Jun and GUO Xian-Jian. Advances in the Study of the MCT Gene Family[J]. Progress In Biochemistry and Biophysics, 2001, 28(2): 172-175 |
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| Authors: | ZHANG Gui-Zhi HUANG Gui-Jun GUO Xian-Jian |
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| Affiliation: | Institute of Respiratory Disease,Xinqiao Hospital,Third Military Medical University, Chongqing 400037,China;Institute of Respiratory Disease,Xinqiao Hospital,Third Military Medical University, Chongqing 400037,China;Institute of Respiratory Disease,Xinqiao Hospital,Third Military Medical University, Chongqing 400037,China |
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| Abstract: | monocarboxylate transporter (MCT) are vital transmembrane transporters involved in multiple cellular functions including the regulation of intracellular pH and lactate transport. At least eight isoforms of MCT have been cloned and characterized to date, they constitute a new gene family of mammal transporters. These isoforms have the differences in substrate and inhibitor specificities and tissue distribution. Thus it may provide a new way of diagonosis and treating for dieases such as cancer by investigating on the structure and function and regulational mechanism of MCT. |
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| Keywords: | monocarboxylate transporter lactate cancer |
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