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Involvement of SPI-2-encoded SpiC in flagellum synthesis in Salmonella enterica serovar Typhimurium
Authors:Kei-ichi Uchiya  Asami Sugita and Toshiaki Nikai
Institution:(1) Department of Microbiology, Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya, Japan
Abstract:

Background  

SpiC encoded within Salmonella pathogeniCity island 2 on the Salmonella enterica serovar Typhimurium chromosome is required for survival within macrophages and systemic infection in mice. Additionally, SpiC contributes to Salmonella-induced activation of the signal transduction pathways in macrophages by affecting the expression of FliC, a component of flagella filaments. Here, we show the contribution of SpiC in flagellum synthesis.
Keywords:
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