Mitochondrial and cell-surface F0F1ATPsynthase in innate and acquired cardioprotection |
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| Authors: | Giovanna Lippe Elena Bisetto Marina Comelli Stefania Contessi Francesca Di Pancrazio Irene Mavelli |
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| Affiliation: | (1) Department of Biomedical Sciences and Technologies and M.A.T.I. Centre of Excellence, University of Udine, P.le Kolbe 4, 33100 Udine, Italy;(2) Present address: Department of Food Science, University of Udine, via Sondrio 2/A, Udine, I-33100, Italy |
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| Abstract: | Mitochondria are central to heart function and dysfunction, and the pathways activated by different cardioprotective interventions mostly converge on mitochondria. In a context of perspectives in innate and acquired cardioprotection, we review some recent advances in F0F1ATPsynthase structure/function and regulation in cardiac cells. We focus on three topics regarding the mitochondrial F0F1ATPsynthase and the plasma membrane enzyme, i.e.: i) the crucial role of cardiac mitochondrial F0F1ATPsynthase regulation by the inhibitory protein IF1 in heart preconditioning strategies; ii) the structure and function of mitochondrial F0F1ATPsynthase oligomers in mammalian myocardium as possible endogenous factors of mitochondria resistance to ischemic insult; iii) the external location and characterization of plasma membrane F0F1 ATP synthase in search for possible actors of its regulation, such as IF1 and calmodulin, at cell surface. |
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| Keywords: | Mitochondrial F0F1ATPsynthase Inhibitory protein IF1 Supra-molecular complexes F0F1ATPsynthase oligomers Cell surface F0F1ATPsynthase Calmodulin Cardioprotection |
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