Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors |
| |
Authors: | Gundersen Eric Fan Kristi Haas Kimberly Huryn Donna Steven Jacobsen J Kreft Anthony Martone Robert Mayer Scott Sonnenberg-Reines June Sun Shaiu-Ching Zhou Hua |
| |
Affiliation: | Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, USA. gundere@wyeth.com |
| |
Abstract: | Alzheimer's disease (AD) is a debilitating disease widely thought to be associated with the accumulation of beta amyloid (Abeta) in the brain. Inhibition of gamma-secretase, one of the enzymes responsible for Abeta production, may be a useful strategy for the treatment of AD. Described below is a series of gamma-secretase inhibitors designed from a scaffold identified by a ROCS [J. Comput. Chem.1996, 17, 1653] search of the corporate database. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|