| 甲硫氨酸腺苷转移酶1A/2A平衡与肝细胞癌 |
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| 引用本文： | 李子涵,熊婷,熊晓丽,卢子贤,周志刚,涂剑. 甲硫氨酸腺苷转移酶1A/2A平衡与肝细胞癌[J]. 生物化学与生物物理进展, 2018, 45(12): 1232-1239 |
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| 作者姓名： | 李子涵 熊婷 熊晓丽 卢子贤 周志刚 涂剑 |
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| 作者单位： | 南华大学药物药理研究所，衡阳 421001,南华大学药物药理研究所，衡阳 421001；长沙医学院，长沙 410219,南华大学药物药理研究所，衡阳 421001,南华大学药物药理研究所，衡阳 421001,南华大学附属第一医院，衡阳 421001,南华大学药物药理研究所，衡阳 421001 |
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| 基金项目： | 国家自然科学基金(81541163)，湖南省教育厅创新平台开放基金(15K111)，南华大学2017年高层次人才科研启动基金(24)和湖南省分子靶标新药研究协同创新中心项目(2016-429)资助 |
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| 摘 要： | 肝细胞癌是一种死亡率极高的癌症,大多数病人发现时已属晚期.甲硫氨酸腺苷转移酶(MAT)是细胞生命活动的关键酶,可以通过催化甲酼氨酸和三磷酸腺苷(ATP)结合,促进生物甲基供体S-腺苷甲酼氨酸(SAMe)的生物合成.正常肝细胞中MAT1A与MAT2A存在动态平衡,共同维持细胞内SAMe稳态;肝细胞癌中MAT1A转变成MAT2A,会使SAMe生物合成减少,为癌细胞生长提供有利条件,故MAT1A表达降低而MAT2A增高.因此,促进MAT2A向MAT1A转化,进而提高MAT1A/MAT2A的比值可能成为治疗肝细胞癌的关键靶点之一.本文就MAT1A/MAT2A平衡在肝细胞癌中的重要作用作一综述,旨在为寻找肝细胞癌防治靶点提供新的思路.
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| 关 键 词： | 甲硫氨酸腺苷转移酶1A，甲硫氨酸腺苷转移酶2A，肝细胞癌，平衡调控 |
| 收稿时间： | 2018-05-05 |
| 修稿时间： | 2018-06-15 |
Equilibrium of Methionine Adenosine Transferase 1A / 2A and Hepatocellular Carcinoma |
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| LI Zi-Han,XIONG Ting,XIONG Xiao-Li,LU Zi-Xian,ZHOU Zhi-Gang and TU Jian. Equilibrium of Methionine Adenosine Transferase 1A / 2A and Hepatocellular Carcinoma[J]. Progress In Biochemistry and Biophysics, 2018, 45(12): 1232-1239 |
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| Authors: | LI Zi-Han XIONG Ting XIONG Xiao-Li LU Zi-Xian ZHOU Zhi-Gang TU Jian |
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| Affiliation: | Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China,Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; Changsha Medical University, Changsha 410219, China,Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China,Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China,The First Affiliated Hospital, University of South China, Hengyang 421001, China and Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China |
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| Abstract: | Hepatocellular carcinoma (HCC) is a kind of cancer with extremely high mortality. Most patients have been in the advanced stage when they went to see the doctor. The enzyme methionine adenosine transferase (MAT), as the key to the survival of the cell, could promote the biosynthesis of the biological methyl donor S-adenosylmethionine (SAMe) by catalyzing the binding of methionine and adenosine triphosphate (ATP). There is a dynamic equilibrium between MAT1A and MAT2A in normal hepatocytes, which maintains the homeostasis of SAMe. The transformation of MAT1A to MAT2A will reduce the biosynthesis of SAMe and provide favorable conditions for the cell growth of HCC. Generally speaking, MAT1A expression is high but MAT2A expression is low in healthy liver tissues while MAT1A is decreased but MAT2A increased in HCC. Therefore, to accelerate the transformation of MAT2A to MAT1A, then improve the MAT1A/MAT2A ratio would be as a key to HCC treatment. This article mainly discusses the transformation of MAT1A to MAT2A in HCC, aiming to find a new way to explore the target for HCC prevention and treatment. |
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| Keywords: | methionine adenosine transferase 1A methionine adenosine transferase 2A hepatocellular carcinoma (HCC) balance control |
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