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Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat |
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| Authors: | P E Hickman B J Horton J R Sabine |
| Abstract: | The diurnal variation in cholesterol synthesis exhibited by rat liver has been examined in fed, fasted, and adrenalectomized animals. Fasting for 3 days caused a lowering of the rate of synthesis but did not abolish the diurnal rhythm. Adrenalectomy abolished the diurnal variation, and caused synthesis to remain at a uniformly high level. We suggest that corticosterone may play an essential role in the daily rhythm of cholesterogenesis. |
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