Role of infection in the pathogenesis of rheumatic diseases |
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Authors: | A N Chandrasekaran Radha Madhavan |
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Institution: | (1) Department of Rheumatology, Madras Medical College and Government General Hospital, 600 003 Madras, India |
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Abstract: | Advanced immunological technology has revealed immunological abnormalities not only in some chronic and autoimmune connective
tissue disorders but also in conditions like infective arthritis where infection apparently seems to play the only role. On
the other hand role of infection in the pathogenesis of some connective tissue disorders has recently gained much importance
from the observation of clinical, pathological and immunological similarities between these diseases and certain infectious
diseases occurring in animal models. Meanwhile, knowledge gained into human leucocyte-A system and its association with certain
diseases opens another angle in etiopathogenesis of certain rheumatic diseases. It has been postulated that adaptive mechanism
of a microbe or the binding between the human leucocyte-A molecule and carbohydrate moiety of a microbe may set up an autoimmune
reaction and in the presence of some triggering factors in the environment may lead on to disease manifestations. An attempt
has been made to discuss the role of infection in the outcome of rheumatic diseases such as septic arthritis, polyarteritis
nodosa, rheumatic fever, enteropathic arthritis, ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematoses
in genetically susceptible individuals producing immunological abnormalities. |
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Keywords: | Role of infection and arthritis rheumatic diseases |
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