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| 以前列腺干细胞抗原为靶点的前列腺癌免疫治疗研究进展 | |
| 引用本文： | 董磊,张晓鹏,于长明,陈薇. 以前列腺干细胞抗原为靶点的前列腺癌免疫治疗研究进展[J]. 生物技术通讯, 2012, 23(2): 291-293 |
| 作者姓名： | 董磊 张晓鹏 于长明 陈薇 |
| 作者单位： | 1. 空军总医院临床检验中心,北京,100142 2. 军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室 北京,100071 3. 军事医学科学院生物工程研究所 北京100071 |
| 摘 要： | 前列腺干细胞抗原(PSCA)为细胞膜表面抗原,在正常前列腺组织中低表达,在雄激素依赖性和非依赖性前列腺癌组织中高表达,有较高的组织特异性,是前列腺癌治疗的理想靶标,近年来以PSCA为靶点的前列腺癌治疗性疫苗的研究已成为热点。我们简要综述以PSCA为靶点治疗前列腺癌的研究进展。 |
| 关 键 词： | 前列腺干细胞抗原 前列腺癌 免疫治疗 |
Research of Immunotherapy for Prostate Cancer Based on Prostate Stem Cell Antigen |
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| DONG Lei , ZHANG Xiao-Peng , YU Chang-Ming , CHEN Wei. Research of Immunotherapy for Prostate Cancer Based on Prostate Stem Cell Antigen[J]. Letters in Biotechnology, 2012, 23(2): 291-293 | |
| Authors: | DONG Lei ZHANG Xiao-Peng YU Chang-Ming CHEN Wei |
| Affiliation: | 1. Clinical Laboratory Center, General Hospital of PLA Air Force, Beijing 100142; 2. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071; 3. Beijing Institute of Biotechnology, Beijing 100071; China) |
| Abstract: | Prostate stem cell antigen（PSCA） is a surface glycoprotein, which is low-expressing in normal prostate and high-expressing in prostate cancer, bladder cancer and pancreatic cancer with higher tissue specificity. As a ideal target of treating prostate cancer, researches of therapeutic vaccine for prostate cancer based on PSCA have became warm spots. This paper presented a review of research progress on therapy of prostate cancer. |
| Keywords: | prostate stem cell antigen prostate cancer immunotherapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |