Optimization of S-adenosyl-L-methionine production by Kluyveromyces lactis on whey in batch culture using a mathematical model |
| |
| Authors: | Kremena Mincheva Veselka Kamburova Venelin Balutzov |
| |
| Institution: | (1) Technological College – Razgrad, University of Rousse, P.O. Box 110, 3 Aprilsko Vastanie Blvd., 7200 Razgrad, Bulgaria;(2) Faculty of Biology, University of Sofia, 8 Dragan Tzankov Blvd., 1421 Sofia, Bulgaria |
| |
| Abstract: | Growth, lactose utilization and S-adenosyl-l-methionine (AdoMet) production by Kluyveromyces lactis AM-65 on whey in batch fermentation were investigated and an unstructured model of the process has been derived. The optimal set of parameters was estimated by fitting the model to experimental results. After incubation for 20 h the optimal fermentation conditions (28.5 °C, pH 5.3, agitation at 270 rpm) resulted in AdoMet production at 1.55 g l–1. |
| |
| Keywords: | Kluyveromyces lactis model optimization S-adenosyl-l-methionine (AdoMet) whey |
| 本文献已被 SpringerLink 等数据库收录！ |
|
