Phosphorylation of ATM/ATR substrates in eukaryotic cells after infection with <Emphasis Type="Italic">Helicobacter pylori</Emphasis> |
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| Authors: | M O Anikeenok Yu N Churin T F Meyer O N Ilinskaya |
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| Institution: | (1) Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA;(2) Chanin 628, 1300 Morris Park Ave, Bronx, NY 10461, USA; |
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| Abstract: | Phosphorylation of ATM-kinase substrates in HeLa and AGS cells in response to Helicobacter pylori infection has been characterized. Infection with wild-type (cagPAI-positive) and corresponding isogenic cagPAI negative mutant induced activation of Chk1 and Chk2 kinases. However, only Chk1 was directly activated by ATM-kinase.
Using 2D-electrophoresis and mass spectrometry a group of proteins phosphorylated in AGS cells by ATM1/ATR kinases during
H. pylori infection has been identified. |
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