<Emphasis Type="Italic">Pseudomonas aeruginosa</Emphasis> β-lactamase induction requires two permeases,AmpG and AmpP |
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| Authors: | Kok-Fai Kong Alian Aguila Lisa Schneper Kalai Mathee |
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| Institution: | 1.Department of Biological Sciences, College of Arts and Sciences,Florida International University,Miami,USA;2.Department of Molecular Microbiology and Infectious Diseases, Herbert Wertheim College of Medicine,Florida International University,Miami,USA |
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| Abstract: | Background In Enterobacteriaceae, β-lactam antibiotic resistance involves murein recycling intermediates. Murein recycling is a complex
process with discrete steps taking place in the periplasm and the cytoplasm. The AmpG permease is critical to this process
as it transports N-acetylglucosamine anhydrous N-acetylmuramyl peptides across the inner membrane. In Pseudomonadaceae, this
intrinsic mechanism remains to be elucidated. Since the mechanism involves two cellular compartments, the characterization
of transporters is crucial to establish the link. |
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