Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study |
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| Authors: | Glennon Richard A Daoud Maha Khalifa Dukat Małgorzata Teitler Milt Herrick-Davis Katharine Purohit Anil Syed Hasan |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA. glennon@hsc.vcu.edu |
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| Abstract: | For a series of monosubstituted arylguanidines, 5-HT3 receptor affinity was found generally related to the electron withdrawing nature of the substituent at the aryl 3-position and the lipophilicity of the 4-position substituent. A broader examination of 35 arylguanidines and arylbiguanides revealed that affinity could be described by molecular polarizability, a Chi index term (8chiP), and the sum of all (-Cl) E-State values (SsCl) in the molecule. |
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