Antidepressant-like effect of MPEP,a potent,selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats |
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| Authors: | Wieronska J M Szewczyk B Branski P Palucha A Pilc A |
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| Affiliation: | (1) Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, PL;(2) Institute of Public Health, Collegium Medicum, Jagiellonian University, Krakow, Poland, PL |
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| Abstract: | Summary. Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats. Received July 2, 2001 Accepted August 6, 2001 Published online June 26, 2002 |
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| Keywords: | : Excitatory amino acids Metabotropic glutamate receptors mGlu5 receptors MPEP Antidepressant effects Olfactory bulbectomy Animal models of depression |
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