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The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding
Authors:Liam B. King  Marnie L. Fusco  Andrew I. Flyak  Philipp A. Ilinykh  Kai Huang  Bronwyn Gunn  Robert N. Kirchdoerfer  Kathryn M. Hastie  Amandeep K. Sangha  Jens Meiler  Galit Alter  Alexander Bukreyev  James E. Crowe  Erica Ollmann Saphire
Affiliation:1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Departments of Pediatrics, Pathology, Microbiology, and Immunology, and the Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA;3. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA;4. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA;5. Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA;6. Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA;7. Galveston National Laboratory, Galveston, TX 77550, USA;8. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:marburgvirus  antibody  hemorrhagic fever  structural biology  Ravn virus  immunotherapeutic  structure  Marburg virus
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