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BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Authors:Rob J.W. Arts  Simone J.C.F.M. Moorlag  Boris Novakovic  Yang Li  Shuang-Yin Wang  Marije Oosting  Vinod Kumar  Ramnik J. Xavier  Cisca Wijmenga  Leo A.B. Joosten  Chantal B.E.M. Reusken  Christine S. Benn  Peter Aaby  Marion P. Koopmans  Hendrik G. Stunnenberg  Reinout van Crevel  Mihai G. Netea
Affiliation:1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands;2. Department of Molecular Biology, Radboud University, Nijmegen, the Netherlands;3. Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands;4. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA, USA;5. Broad Institute of MIT and Harvard University, Cambridge, MA, USA;6. Department Viroscience, WHO Collaborating Centre for Arboviruses and Viral Hemorrhagic Fever Reference and Research, Erasmus University Medical Center, Rotterdam, the Netherlands;7. Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark;8. OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark;9. Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany
Abstract:
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  • Keywords:trained immunity  BCG  yellow fever vaccine  epigenetics  monocytes  IL-1  innate immune memory  non-specific effects of vaccines
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