Apolipoprotein A-I attenuates renal ischemia/reperfusion injury in rats |
| |
Authors: | Ning Shi Man-Ping Wu |
| |
Institution: | (1) Department of Biochemistry, School of Pharmacy, Fudan University, P.O. Box 257, No. 138 Yixueyuan Road, Shanghai, 200032, China |
| |
Abstract: | Apolipoprotein A-I (ApoA-I), the major protein component of serum high-density lipoprotein (HDL), exhibits its anti-inflammatory
activity in inflammatory responses. As renal inflammation plays an important role in ischemia/reperfusion (I/R) injury of
the kidney, the aim of this study was to investigate the beneficial effect of ApoA-I on renal I/R injury in rats and the underlined
mechanism. Using rats subjected to renal I/R by occlusion of bilateral renal pedicles, we found that administration of ApoA-I
significantly reduced serum creatinine levels, serum TNF-α and IL-1β levels as well as tissue myeloperoxidase (MPO) activity,
compared with I/R controls. Moreover, ApoA-I treatment suppresses the expression of intercellular adhesion molecules-1 (ICAM-1)
and P-selectin on endothelium, thus diminishing neutrophil adherence and the subsequent tissue injury. These results showed
that ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. It
seems likely that ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration
and activation. |
| |
Keywords: | Apolipoprotein A-I Ischemia/reperfusion Myeloperoxidase Neutrophil Cytokines |
本文献已被 PubMed SpringerLink 等数据库收录! |
|