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| 海洋真菌Fusarium sp.次级代谢产物的研究 | |
| 引用本文： | 刘涛,李占林,王宇,田黎,裴月湖,华会明.海洋真菌Fusarium sp.次级代谢产物的研究[J].天然产物研究与开发,2012,24(8):1047-1050. |
| 作者姓名： | 刘涛 李占林 王宇 田黎 裴月湖 华会明 |
| 作者单位： | 1. 中国医科大学药学院,沈阳,110001 2. 沈阳药科大学创新药物研究与设计教育部重点实验室,沈阳,110016 3. 国家海洋局第一海洋研究所,青岛266061;青岛科技大学,青岛266042 |
| 基金项目： | 国家自然科学基金(20872094);国家863项目(2007AA09Z413,2007AA09Z435) |
| 摘 要： | 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、开放ODS柱色谱以及HPLC等方法从海洋真菌Fusarium sp.的菌丝体中分离得到5个化合物,通过波谱数据及理化性质分别鉴定为3β,15β-二羟基-(22E,24R)-麦角甾-5,8(14),22-三烯-7-酮(1)、3β,5α,9α-三羟基-(22E,24R)-麦角甾-7,22-二烯-6-酮(2)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(3)、5α,8α-过氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇(4)和丁二酸(5).其中化合物1和2首次从该属真菌中分离得到. |
| 关 键 词： | 海洋真菌 镰孢霉属真菌 次级代谢产物 麦角甾醇 |
Secondary Metabolites from Marine Fungus Fusarium sp. |
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| LIU Tao , LI Zhan-lin , WANG Yu , TIAN Li , PEI Yue-hu , HUA Hui-ming.Secondary Metabolites from Marine Fungus Fusarium sp.[J].Natural Product Research and Development,2012,24(8):1047-1050. | |
| Authors: | LIU Tao LI Zhan-lin WANG Yu TIAN Li PEI Yue-hu HUA Hui-ming |
| Institution: | 1School of Pharmaceutical Sciences,China Medical University,Shenyang 110001,China;2Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China;3The First Institute of Oceanography SOA,Qingdao 266061,China;4Qingdao University of Science & Technology,Qingdao 266042,China |
| Abstract: | Five compounds were isolated and purified from the mycelia of marine fungus Fusarium sp.by using silica gel,Sephadex LH-20,open ODS column chromatography and HPLC.On the basis of spectral data and physicochemical properties,their structures were elucidated as 3β,15β-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-triene-7-one(1),3β,5α,9α-trihydroxyl-(22E,24R)-ergosta-7,22-diene-6-one(2),(22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol(3),5α,8α-epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol(4),and amber acid(5).Compounds 1 and 2 were isolated for the first time from this genus of marine fungus. |
| Keywords: | marine fungus Fusarium sp secondary metabolite ergosterol |
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