3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands. |
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| Authors: | M Kanyonyo S J Govaerts E Hermans J H Poupaert D M Lambert |
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| Affiliation: | Unité de Chimie Pharmaceutique et de Radiopharmacie, Université Catholiqué de Louvain, Bruxelles, Belgium. |
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| Abstract: | Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists. |
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