Selective depletion of activated T cells: the CD40L-specific antibody experience |
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Authors: | Hargreaves Roseanna E G Monk Nicola J Jurcevic Stipo |
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Affiliation: | Department of Nephrology & Transplantation, King's College, Guy's, King's and St Thomas' Medical School, Guy's Hospital, London, SE1 9RT, UK. |
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Abstract: | Blocking the signal that provides co-stimulation to T cells during their encounter with antigen is thought to make T cells anergic or tolerant. Recently, treatments using CD40L-specific antibody, a co-stimulation blocking reagent, in primate transplant models indicated that this elegant concept could finally be turning into reality. In this context, the finding that CD40L-specific antibody acts through depletion of activated T cells rather than through co-stimulation blockade might seem undesirable. However, the selective removal of cells that are key effectors of immunopathology could provide a powerful tool for containing unwanted immune responses such as those that mediate autoimmune diseases and transplant rejection. |
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