Muraymycins,novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues |
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| Authors: | Yamashita Ayako Norton Emily Petersen Peter J Rasmussen Beth A Singh Guy Yang Youjin Mansour Tarek S Ho Douglas M |
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| Institution: | Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA. yamashita@wyeth.com |
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| Abstract: | A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II. |
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