Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review |
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Authors: | Najla Fiaturi John J Castellot Jr Heber C Nielsen |
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Institution: | 1. Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, 02111, USA 2. Department of Pediatrics, Tufts Medical Center, Boston, MA, 02111, USA
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Abstract: | Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks gestation. Proper lung development from 23–28 weeks requires coordinated cell proliferation and differentiation. Infants born at this age are at high risk for respiratory distress syndrome (RDS), a lung disease characterized by insufficient surfactant production due to immaturity of the alveoli and its constituent cells in the lung. The ErbB4 receptor and its stimulation by neuregulin (NRG) plays a critical role in surfactant synthesis by alveolar type II epithelial cells. In this review, we first provide an introduction to normal human alveolar development, followed by a discussion of the neuregulin and ErbB4-mediated mechanisms regulating alveolar development and surfactant production. |
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Keywords: | ErbB4 Neuregulin TACE Gamma Secretase Pulmonary Surfactant Presenilin 4ICD |
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