Manifestation of synergism under simultaneous action of hyperthermia and antitumor drugs on yeast cells

For the purpose of obtaining novel fundamental knowledge, there are studied regularities of manifestation of synergism under simultaneous combined action of hyperthermia (47.5–60°C) and antitumor compounds (cyclophosphamide, cisplatin) on survival of yeast cells. To calculate the efficiency of synergic interaction, we used experimentally obtained dependences of cell survival on the duration of action after separate and simultaneous action of chemical agent and hyperthermia. A certain diapason of temperatures is shown, within which a synergic increase of the action of antitumor drug and hyperthermia occurs. Any deviation of temperature from the optimal value leads to a decrease of synergism. A possible mechanism of the revealed regularity is discussed.