Carboxylate anion binding in the cyclohexaamylose cavity: A steric and electronic evaluation |
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Authors: | Raymond J Bergeron Michael Almy Channing Kathy Ann McGovern William Peyton Roberts |
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Institution: | Department of Medicinal Chemistry, Box J-4, Hillis Miller Health Center, University of Florida, Gainesville, Florida 32610 USA |
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Abstract: | This investigation focuses on the steric and electronic requirements for the binding of carboxylate anions in the cyclohexaamylose cavity. The geometries and thermodynamic stabilities of the 3,5-dimethyl-4-hydroxybenzoic acid, 3,5-dimethyl-4-hydroxycinnamic acid, and 3,5-dimethyl-4-hydroxyhydrocinnamic acid cyclohexaamylose complexes are evaluated at pH = 7.60 and 12.00. Results indicate that the carboxylate anions of 3,5-dimethyl-4-hydroxycinnamic acid and 3,5-dimethyl-4-hydroxyhydrocinnamic acid bind in the cyclohexaamylose cavity at both pH = 7.60 and 12.00. In addition, the dependence of the stability of the resulting complexes on pH is shown to be marginal. These findings suggest that if a carboxylate anion is to bind in the cyclohexaamylose cavity, it must be able to adopt a position in the cavity which allows for at least partial solvation of charge. |
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