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Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability |
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| Authors: | Tong Yunsong Lin Nan-Horng Wang Le Hasvold Lisa Wang Weibo Leonard Nicholas Li Tongmei Li Qun Cohen Jerry Gu Wen-Zhen Zhang Haiying Stoll Vincent Bauch Joy Marsh Kennan Rosenberg Saul H Sham Hing L |
| Affiliation: | R47B, AP10, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. yunsong.tong@abbott.com |
| Abstract: | A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics. |
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