Therapeutic potential of CD4+ CD25+ regulatory T cells in allogeneic transplantation |
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| Authors: | Cohen J L Salomon B L |
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| Institution: | 1. Department of Neurology, The Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, USA;2. Louisiana State University, Baton Rouge, LA, USA;3. Neuro-oncology Research Group, Department of Neurosurgery, Cancer Center Amsterdam, and VU University Medical Center, Amsterdam, The Netherlands;1. University of California Davis School of Medicine, Sacramento, CA, USA;2. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;3. Pentara, Millcreek, UT, USA;4. Capricor Therapeutics, Beverly Hills, CA, USA;5. Atom International, Newcastle upon Tyne, UK;6. Nemours Children''s Hospital, Orlando, FL, USA;7. St Jude Children''s Research Hospital, Memphis, TN, USA;8. Cincinnati Children''s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA;9. University of Colorado, Children''s Hospital Colorado, Denver, CO, USA;10. Medical College of Wisconsin, Milwaukee, WI, USA;11. Washington University School of Medicine, St Louis, MO, USA;12. Nationwide Children''s Hospital, Columbus, OH, USA;13. Children''s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA;14. Parent Project Muscular Dystrophy, Hackensack, NJ, USA;1. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA;2. Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA;1. Department of Basic Science, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran;2. Behavioral Science Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran;3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran;4. Department of Cellular and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C., Tehran, Islamic Republic of Iran |
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| Abstract: | The subpopulation of CD4+ CD25+ immunoregulatory T cells constitutes less than of the entire CD4+ T-cell pool in mice and 2% in humans. These cells play a crucial role in the control of autoimmune processes. More recently, in vitro and in vivo data also indicate that CD4+ CD25+ immunoregulatory T cells can regulate alloreactivity. This renders them good candidates for innovative strategies in the field of transplantation. Inducing a state of immune tolerance with immunoregulatory T cells would alleviate the need for immunosuppression, and the occurrence of late allograft failure represents a major goal of transplantation immunology. Here we discuss how these naturally occurring CD4+ CD25+ immunoregulatory T cells can be used to modulate alloreactivity in hematopoietic stem cell and solid organ transplantation. |
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