Enhanced clearing of Helicobacter pylori after omeprazole plus roxithromycin treatment |
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Authors: | Luigina Cellini Leonardo Marzio Arturo Di Girolamo Nerino Allocati Laurino Grossi Benedetto Dainelli |
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Institution: | Istituto di Medicina Sperimentale, Università G.D'Annunzio, Chieti, Italy. |
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Abstract: | The in vitro antibacterial activity of omeprazole against eight strains of Helicobacter pylori was evaluated. Minimum inhibitory concentration (MIC) values were 32 micrograms/ml and 64 micrograms/ml (MIC50 and MIC90 respectively). We performed a randomized single blind study comparing the efficacy of omeprazole alone (for 4 weeks) or combined with roxithromycin (for 2 weeks) in the treatment of duodenal ulcer and chronic active gastritis associated with H. pylori infection, H. pylori was eradicated in 75% of patients treated with omeprazole alone whereas the patients treated with the combination of these drugs were completely free from H. pylori at the end of the therapy. |
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Keywords: | Helicobacter pylori Omeprazole Roxithromycin Gastritis Duodenal ulcer |
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