Circadian rhythms in the phosphorylation of rat liver histones and similar basic proteins |
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Authors: | K Letnansky L Reisinger |
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Institution: | 1. Institute for Cancer Research of the University of Vienna, Vienna, Austria;2. Institute for Statistics of the University of Vienna, Vienna, Austria |
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Abstract: | In the rat liver, the phosphorylation of histones is subject to a circadian rhythm. Most classes of histones, which had been obtained by polyacrylamide gel electrophoresis of nuclear HCl-extracts, exhibited maximum phosphorylation at 21.00 h and at 08.00 h. This is in correlation to maxima of RNA synthesis (23.00 h) and protein synthesis (24.00 h and 12.00 h), reported in the literature. A series of basic proteins, not as yet described, could be separated from the histones. These proteins exhibit a high extent of phosphorylation and a rhythmicity analogous to that of the histones. It is suggested that these proteins are of importance in the expression of genetic information. |
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