Prostaglandin controls Neuromuscular Transmission in Guinea-pig Vas Deferens |
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Authors: | P HEDQVIST U S VON EULER |
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Institution: | 1.Department of Physiology,Karolinska Institutet,Stockholm |
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Abstract: | PROSTAGLANDINS of the E type (PGE1, PGE2) inhibit sympathetic neurotransmission in several tissues and species1–4. On the basis of their natural occurrence and availability for release, as well as observations on the pharmacological actions of the PGs, endogenous PGE1 and PGE2 are postulated to operate on sympathetic neurotransmission by a feedback mechanism and thereby modulate the effector responses to nerve activity1, 5. Inhibition by 5,8,11,14-eicosatetraynoic acid (ETA) of PG synthesis in the cat spleen and in the rabbit heart increases the release of noradrenaline (NA) in response to nerve stimulation, thus strongly supporting the hypothesis6, 7. We report here that guinea-pig vas deferens releases PG in response to nerve stimulation and that the neuromuscular transmission is facilitated after inhibition of PG synthesis. PG synthesis was irreversibly inhibited using ETA8. |
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