X-ray-induced mutations affecting the level of the enzyme alcohol dehydrogenase in Drosophila melanogaster: frequency and genetic analysis of null-enzyme mutants. |
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Authors: | C S Aaron |
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Institution: | J.A. Cohen Institute, Interuniversity Institute for Radiation Protection and Radiation Pathology, Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Wassenaarseweg 72 Leiden, The Netherlands |
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Abstract: | The frequency of X-ray-induced (null-enzyme) mutations at the alcohol dehydrogenase locus in Drosophila melanogaster was measured. The rate of recovery of chromosomes that fail to direct the synthesis of a functional Adh protein is 3 x 10(-8) per R for chromosomes that do not include large chromosome rearrangements. However, this analysis excludes a larger number of chromosomes that are "null-enzyme mutations" because thye are deleted for the region of the Adh locus. The dose of X-rays required to induce a frequency of non-deletion null-enzyme mutants equal to the spontaneous frequency is about 73 rad calculated from the data reported in this communication. |
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Keywords: | Reprint requests should be sent to: Dr Charles S Aaron Department of Zoology Louisiana State University Baton Rouge LA 70893 U S A |
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