The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. |
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Authors: | C E Seyfried V L Schweickart R Godiska P W Gray |
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Institution: | ICOS Corporation, Bothell, Washington 98021. |
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Abstract: | Platelet-activating factor (PAF), a phospholipid, exhibits a variety of potent inflammatory bioactivities that are mediated by a specific cell surface receptor. The gene for the human PAF receptor (PTAFR) has been isolated by hybridization with a guinea pig probe. The coding sequence contains no intervening sequences. The encoded protein is highly homologous to the guinea pig PAF receptor (82% identity) and contains seven putative transmembrane domains. The PAF receptor therefore appears to be a member of the G protein coupled family of receptors and exhibits significant similarity to many members of the family. Analysis of somatic cell hybrids suggests that the PAF receptor is encoded by a single gene on human chromosome 1. |
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