Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin |
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Authors: | Stabler Cherie L Sun Xue-Long Cui Wanxing Wilson John T Haller Carolyn A Chaikof Elliot L |
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Institution: | Department of Surgery, Emory University, Atlanta, GA 30322, USA. |
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Abstract: | Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses. |
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