Production of superoxide dismutases from Proteus mirabilis and Proteus vulgaris |
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| Authors: | Tressia M Dayton Karen A Diefenbach Michelle L Fuller Joshua Valtos Eric C Niederhoffer |
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| Institution: | (1) Department of Chemistry and Biochemistry, Southern Illinois University at Carbondale, Carbondale, IL, USA;(2) Department of Microbiology, Southern Illinois University at Carbondale, Carbondale, IL, USA;(3) Department of Medical Biochemistry, Southern Illinois University at Carbondale, Carbondale, IL, USA;(4) Medical Biochemistry, School of Medicine, Southern Illinois University at Carbondale, 62901-4413 Carbondale, IL, USA |
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| Abstract: | Proteus mirabilis and Proteus vulgaris expressed a combination of superoxide dismutase (Sod) activities, which was assigned to FeSod1, FeSod2 and MnSod for P. mirabilis, and FeSod, MnSod and CuZnSod for P. vulgaris. Production of the Sod proteins was dependent on the availability of iron, whether cells were grown under anaerobiosis or aerobiosis and growth phase. Nalidixic acid and chloramphenicol inhibited cell growth and the iron- and dioxygen-dependent production of Sod. These results support the involvement of metal ions and redox status in the production of Proteus Sods. |
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| Keywords: | Superoxide dismutase Proteus iron metabolism pathogen |
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