Multiple forms of monoamine oxidase in rabbit platelets. |
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| Authors: | D J Edwards S S Chang |
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| Institution: | Department of Psychiatry, Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh, PA. 15261, USA |
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| Abstract: | Rabbit platelets were found to contain both types A and B MAO activities. The specific enzymatic activity of rabbit platelet MAO was higher for the substrate serotonin than for phenylethylamine. The Km's for rabbit platelet MAO indicated that the MAO-B enzyme was similar to human platelet MAO and that both MAO-A and MAO-B enzymes in the rabbit platelet are similar to the corresponding forms in the rabbit brain. The drugs clorgyline and deprenyl confirmed the existence of types A and B MAO in the platelet and furthermore indicated that the type A form accounted for approximately 90% of the total enzymatic activity. Amitriptyline at low (micromolar) concentrations selectively inhibited MAO-B activity in both rabbit platelets and brain. |
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