Fused Toes Homolog modulates radiation cytotoxicity in uterine cervical cancer cells |
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Authors: | Arunkumar Anandharaj Senthilkumar Cinghu Won-Dong Kim Jae-Ran Yu Woo-Yoon Park |
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Institution: | (1) Department of Radiation Oncology, Chungbuk National University College of Medicine, Cheongju, 361-763, Republic of Korea;(2) Department of Environmental and Tropical Medicine, Konkuk University College of Medicine, Chungju, 380-701, Republic of Korea; |
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Abstract: | Radiotherapy is the major treatment modality for uterine cervical cancer, but in some cases, the disease is radioresistant.
Defining the molecular events that contribute to radioresistance and progression of cancer are of critical importance. Here
we evaluated the role of Fused Toes Homolog (FTS) in radiation resistance of cervical carcinoma. Immunostaning of cervical
cancer cells and tissues revealed that FTS localization and expression was changed after radiation. Targeted stable knockdown
of FTS in HeLa cells led to the growth inhibition after radiation. Radiation induced AKT mediated cytoprotective effect was
countered by FTS knockdown which leads to PARP cleavage and caspase-3 activation leading to cell death. FTS knockdown promotes
radiation induced cell cycle arrest at G0/G1 and apoptosis of HeLa cells with concurrent alterations in the display of cell
cycle regulatory proteins. This study revealed FTS is involved in radioresistance of cervical cancer. Targeted inhibition
of FTS led to the shutdown of key elemental characteristics of cervical cancer and could lead to an effective therapeutic
strategy. |
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